297: 10,000 Structures Are Not Enough: The Data Gap Limiting De Novo Antibody Design with David Younger - Part 1

AI antibody design is bottlenecked by structural and affinity data scarcity, not modeling technique, per A-Alpha Bio's CEO.

• Data scarcity underestimated: Younger argues the field vastly underestimates data needs for AI-driven protein design; public datasets (outside PDB) lack proper controls/annotations for binding and affinity.
• AlphaSeq platform: A-Alpha Bio's engineered yeast mating system measures protein-protein interactions in batch, turning a million-interaction experiment into one flask instead of one well per interaction.

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