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PodcastLatent SpaceSeptember 23, 2026

🔬Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)

Radical Numerics argues the same GLMs that enable dangerous biological design must also power biodefense, which is currently far behind.

  • Radical Numerics' Omni model: Eric Nguyen's new genome language model beats prior specialist tools (Borzoi, EVO2) and even CADD's ensemble on ClinVar/TraitGym variant-effect benchmarks, especially in non-coding regions (~98.5% of the genome).
  • Chain-of-thought in DNA: Fed only progressively higher-scoring RNA aptamers during mid-training, Omni extrapolated to recreate held-out top-scoring sequences it had never seen, in silico.

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